Pyrexia of unknown origin causes

Infections Can Make Undergraduates Die

  • Infection (20-40%)
    • Tuberculosis
    • Infective endocarditis
    • Epstein-Barr virus (EBV)
    • Cytomegalovirus (CMV)
  • Connective tissue disorders (20%)
    • Rheumatoid arthritis
    • Systemic Lupus Erythematosus
    • Adult-onset Still’s disease
    • Temporal arteritis
  • Malignancy (10-20%)
    • Lymphoma
    • Leukaemia
    • Hepatocellular carcinoma
  • Undiagnosed (20%)
  • Drugs (e.g. phenytoin) (Rare)

* Relative percentages in brackets

Pyrexia of unknown origin (PUO) is a fever > 3 weeks with no cause found despite 7 days in hospital with investigations.

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