Splenomegaly causes

CHINA

  • Congestion – portal hypertension
  • Haematological – haemolytic anaemia, sickle cell disease
  • Infection – malaria, EBV, CMV, HIV
  • Neoplasm – CML, myelofibrosis, lymphoma
  • Autoimmune – RA, sarcoidosis, amyloidosis

Causes of Massive splenomegaly (three M’s):

  • chronic Myeloid leukaemia
  • Myelofibrosis
  • Malaria
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