Systemic Lupus Erythematosus (SLE) diagnostic criteria

MD SOAP BRAIN

  • Malar rash – butterfly rash, sparing of nasolabial folds
  • Discoid rash – basement membrane involved, may cause scarring
  • Serositis – pleuritis/pericarditis
  • Oral ulcers
  • Antinuclear antibody (ANA) – very sensitive test
  • Photosensitivity – skin rash to sunlight
  • Blood – haemolytic anaemia, leukopaenia, thrombocytopaenia
  • Renal disorder – proteinuria and cell casts
  • Arthritis – symmetrical, involving 2+ small or large peripheral joints
  • Immunological disorder – anti-dsDNA
  • Neurological – seizures, psychosis
American College of Rheumatology, 1997: requires 4 out of 11
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