Crohn’s disease pathophysiology and features

CHRIS Has Too Much Watery Diarrhoea and Abdominal pain

  • Cobblestone appearance of mucosa
  • High temperature
  • Reduced lumen size / Rose-thorn ulcers
  • Ileocecal region commonly involved
  • Skip lesions
  • Hyperplasia of mesenteric lymph nodes
  • Transmural inflammation (all layers, may ulcerate)
  • Malabsorption
  • Weight loss
  • Diarrhoea (watery)
  • Abdominal pain




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